There follow several pages of qualifications, guidelines and commentary including definitions of "healthy development," "normal progress," "free and unified society" and other terms; what consititutes interference with the social development; when Prime Directive provisions may be overridden and by whom; penalties for violations, First Contact protocols, et cetera.
Penalties for violation of the Prime Directive are severe. The minimum penalty for a wilfull violation is a dishonourable discharge; more severe violations carry punishments up life imprisonment.
General Order Number Seven
This order forbids any contact with the planet Talos IV. It provides the only death penalty on the books. Information on the Talos Star Group is classified SECLAR 4.
General Order Number Twelve
This order establishes protocols for making communications contact with approaching space vessels and the approach of space vessels with which communications contact has not been established.
General Order Number Thirteen
This order establishes protoicols for the evacuation of Starfleet vessels.
General Order Number Fifteen
This order establishes security protocols for Away Teams. It states, in part, "No Flag officer shall beam into a hazardous situation without armed escort." Under this order, a ship's Executive Officer can recommend that the Captain of the ship not accompany an Away Team until the area has been secured.
General Order Number Twenty-Four
This order provides for the orbital bombardment of a hostile planet. It is only used in time of war.

This section summarises a sampling of Starfleet Directives. They are usually summaries of a constellation of General Orders and Starfleet Regulations.
Prime Directive
See General Order Number One, above.
The Omega Directive
Denoted by Ω is a highly classified Starfleet general order requiring the captain of a starship to notify Starfleet Command immediately upon detection of an Omega molecule—The directive also authorises the use of any and all means to destroy an Omega molecule, superseding all other regulations, even the Prime Directive. The Omega Directive was deemed necessary because of the extreme power and the threat to interstellar civilizations posed by even a single molecule. Knowledge of the Omega molecule and the Omega Directive is restricted to starship captains and flag officers.
The Temporal Prime Directive
This is a fundamental Starfleet principle. All Starfleet personnel are strictly forbidden from directly interfering with historical events and were required to maintain the timeline and prevent history from being altered. It also restricts people from telling too much about the future, so as not to cause paradoxes or alter the timeline.
Directive 010
"Before engaging alien species in battle, any and all attempts to make first contact and achieve nonmilitary resolution must be made."
Directive 101:
Any individual accused of a crime does not have to answer any questions. This is a reference to the Seventh Guarantee of the Constitution of the United Federation of Planets.
Tactical Directive 36:
"The captain will not engage a hostile force without the protection of a security officer." This incorpoates General Order Fifteen, above

This section summarises a sampling of Starfleet Regulations. Regulations are cited by number and section, and may be refereed to as "Regulations," "Orders," or "Codes." Regulation 46, section A might be referred to as "Regulation 46A," "Order 46, section A" or "Code 46A."
Regulation 46
Establishes communications protocols in combat situations.